Concise Synthesis of Ring-Fission Metabolites of Epicatechin: 5-(3,4-Dihydroxybenzyl)dihydrofuran-2(3H)-one M6 |
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| Authors: | Xiaowei Chang Yin-Fang Yao Jan Koek |
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| Institution: | 1. Unilever Discover Shanghai , Shanghai, China;2. Unilever Discover Vlaardingen , Vlaardingen, The Netherlands |
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| Abstract: | The ring-fission metabolites of epicatechin, 5-(3,4-dihydroxybenzyl)dihydrofuran-2(3H)-one M6 and 3-methylated M6, were prepared from 3,4-dihydroxybenzaldehyde and furan-2(5H)-one using two new concise methods in excellent yields (three or two steps in 40–60% overall yield). |
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| Keywords: | 5-(3 4-Dihydroxybenzyl)dihydrofuran-2(3H)-one epicatechin metabolite methylated M6 |
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