|
|||||
|
|
An Efficient Method for Preparing the α-Deuterated-α,β-Unsaturated Carbonyl Compounds by Reaction of Stable Phosphonium Ylides with Carbonyl Compounds in Deuterium Oxide |
|
| Authors: | Yung-Son Hon Tzyy-Rong Sheu Chia-Fu Lee |
| Institution: | Department of Chemistry , National Chung-Cheng University , Chia-Yi, Taiwan, 621, Republic of China |
| Abstract: | Carbonyl compounds reacted with stable phosphonium ylides in D2O to give α-deuterated-α,β-unsaturated carbonyl compounds in the same flask. The chemical yield and deuterium incorporation are excellent under our procedure. The fragile group like ozonide was compatible with our reaction condition. |
| Keywords: | Hydrazonoyl halides isoxazolo[3 4‐d]pyridazines pyrazolo[3 4‐d]pyridazines triazolino[4 3‐a]pyrimidines thieno[2 3‐b]pyrimidines |