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Concise and Efficient Synthesis of Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors |
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| Authors: | Abdul M Rasheed Rambabu Namala Narendra Manne Sreelatha Vanjivaka Ravi Dhamjewar Gopalan Balasubramanian |
| Institution: | 1. Matrix Laboratories , Hyderabad, India abdul.rasheed@gvkbio.com;3. Matrix Laboratories , Hyderabad, India |
| Abstract: | Highly potent and selective DPP II inhibitors N′‐(4‐Chlorobenzyl)‐N′‐methyl‐4‐oxo‐4‐(1‐piperidinyl)‐1,3‐(S)‐butane‐diamine dihydrochloride 1 and N′‐(4‐chlorobenzyl)‐4‐oxo‐4‐(1‐piperidinyl)‐1,3‐(S)‐butanediamine dihydrochloride 2 have been efficiently synthesized starting from L‐glutamine. A short and high yielding route with simple isolation techniques has been disclosed. |
| Keywords: | DPP II inhibitors L‐glutamine" target="_blank">L‐glutamine Hoffmann rearrangement reductive amination |