Tribromo Phloroglucinol as a Novel and Highly Efficient Reagent for the Conversion of Benzothioamides to the Corresponding 1,2,4-Thiadiazoles |
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| Authors: | Hassan Zali-Boeini Seyed Gholamhossein Mansouri |
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| Affiliation: | 1. Department of Chemistry, University of Isfahan, Isfahan, Iranh.zali@chem.ui.ac.ir;3. Department of Chemistry, University of Isfahan, Isfahan, Iran |
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| Abstract: | 2,4,6-Tribromo-1,3,5-trihydroxybenzene (TBTHB) as a reagent was efficiently reacted with 6 molar equivalents of benzothioamides in dimethyl sulfoxide (DMSO), and the corresponding 3,5-diaryl-1,2,4-thiadiazoles were obtained in almost quantitative yields (91–98%) and in short times (15–20 min) with the formation of hexahydroxybenzene as a rather valuable by-product. |
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| Keywords: | Heterocycles thiadiazole thioamide |
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