Tribromo Phloroglucinol as a Novel and Highly Efficient Reagent for the Conversion of Benzothioamides to the Corresponding 1,2,4-Thiadiazoles |
| |
| Authors: | Hassan Zali-Boeini Seyed Gholamhossein Mansouri |
| |
| Institution: | 1. Department of Chemistry, University of Isfahan, Isfahan, Iranh.zali@chem.ui.ac.ir;3. Department of Chemistry, University of Isfahan, Isfahan, Iran |
| |
| Abstract: | 2,4,6-Tribromo-1,3,5-trihydroxybenzene (TBTHB) as a reagent was efficiently reacted with 6 molar equivalents of benzothioamides in dimethyl sulfoxide (DMSO), and the corresponding 3,5-diaryl-1,2,4-thiadiazoles were obtained in almost quantitative yields (91–98%) and in short times (15–20 min) with the formation of hexahydroxybenzene as a rather valuable by-product. |
| |
| Keywords: | Heterocycles thiadiazole thioamide |
|
|
