Department of Chemistry , Xiamen University , Fujian, Xiamen, 361005, PR CHINA
Abstract:
A flexible approach to protected trans-5-alkyl-4-hydroxy-2-pyrrolidinones was described. The key step involved the α-amidoalkylation of benzene-sulfone derived from (S)-malic acid, with organozinc reagents generated in situ from Grignard reagents and anhydrous ZnCl2-OEt2.