P2O5-Promoted Efficient and Diastereoselective Synthesis of Substituted 5-Methylene-dihydropyran-2,6-diones and 3-Methylene-3,4-dihydropyran-2-ones |
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| Authors: | Vijay Singh Sudharshan Madapa |
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| Affiliation: | Medicinal and Process Chemistry Division, Central Drug Research Institute , Lucknow, India |
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| Abstract: | A simple, efficient, and diastereoselective synthesis of 5-methylene-dihydropyran-2,6-diones and 3-methylene-3,4-dihydropyran-2-ones from substrates afforded by the SN2 reaction between the acetyl derivatives of the Baylis–Hillman adducts and methylacetoacetate or acetylacetone or benzoyl acetone via saponification followed by P2O5-mediated cyclization is described. |
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| Keywords: | Baylis–Hillman 5-methylene-dihydropyran-2,6-diones 3-methylene-3,4-dihydropyran-2-ones P2O5 |
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