Synthesis of (R)-Selegiline via Hydrolytic Kinetic Resolution

A short and enantioselective formal synthesis of (R)-selegiline has been achieved using Jacobsen's hydrolytic kinetic resolution (HKR) of phenyl propylene oxide.

Keywords: Cobalt-based chiral salen complex, hydrolytic kinetic resolution, MAO inhibitors, phenyl propylene oxide, selegiline

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ACKNOWLEDGMENTS

N. B. K. thanks the Council of Scientific and Industrial Research, New Delhi, for the award of a senior research fellowship. Financial support in the form of a research grant from the Department of Science and Technology, New Delhi, is gratefully acknowledged.