3-Carboxylate-Substituted Isoindolinones in K2CO3-Catalyzed Michael Reactions |
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| Authors: | Francesco Scorzelli Laura Palombi Rosanna Filosa Antonio Massa |
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| Affiliation: | 1. Dipartimento di Chimica e Biologia, Università di Salerno, Fisciano, Italy;2. Dipartimento di Medicina Sperimentale, Università di Napoli, Napoli, Italy |
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| Abstract: | Activated 3-substituted isoindolinones have proved to be efficient nucleophiles in K2CO3-catalyzed Michael reactions of several types of electron-deficient olefins. Moreover, tricyclic pyrrolizidines have been conveniently synthesized via a modification of the described general protocol as a consequence of a cascade Michael/cyclization reaction of unsaturated aldehydes. |
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| Keywords: | Conjugated addition isoindolinones nitrogen heterocycles pyrrolizidines synthetic methods |
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