Tandem Ring Opening and Oximation of Ethyl 3‐Aroyl‐1‐cyano‐4‐hydroxy‐2,4,6‐triarylcyclohexanecarboxylate by Hydroxylamine |
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| Authors: | Sivaperuman Saravanan Heeralal Vignesh Babu |
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| Institution: | Department of Organic Chemistry , Madurai Kamaraj University , Madurai, India |
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| Abstract: | The reaction of hydroxylamine hydrochloride with ethyl 3‐aroyl‐1‐cyano‐4‐hydroxy‐2,4,6‐triarylcyclohexanecarboxylate has led to the formation of ethyl 2‐amino(hydroxyimino)methyl]‐3‐aryl‐5‐(hydroxyimino)‐5‐arylpentanoate via a tandem ring opening and oximation process. The structures of the products are confirmed by NMR and X‐ray techniques, and the conformational features of the product arrived at are compared with a molecular dynamics simulation study. |
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| Keywords: | 3‐aroyl‐1‐cyano‐4‐hydroxy‐2 4 6‐triarylcyclohexanecarboxylate NMR analysis PM3 calculation tandem reaction X‐ray structure |
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