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New Procedure for the Synthesis of 2-Alkylbenzimidazoles |
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| Authors: | Tomohiro Yamashita Shozo Yamada Yasundo Yamazaki Hideo Tanaka |
| Affiliation: | 1. Department of Applied Chemistry , Faculty of Engineering, Okayama University , Okayama, Japan tomyamas@taiho.co.jp;3. Chemical Technology Laboratory, Taiho Pharmaceutical Co. , Saitama, Japan;4. Discovery and Development Laboratory II, Hanno Research Center, Taiho Pharmaceutical Co. , Hanno, Saitama, Japan;5. Department of Applied Chemistry , Faculty of Engineering, Okayama University , Okayama, Japan |
| Abstract: | Simple, economical, and environmentally friendly method to synthesize 2-alkylbenzimidazoles was developed by modifying the conventional method between o-phenylenediamine and aldehyde. |
| Keywords: | Benzimidazoles o-phenylenediamine sodium hydrogen sulfite |