Tetralone Esters as Intermediates for the Synthesis of Podophyllotoxin Derivatives Via Cyclopropanation of Chalcones |
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| Authors: | N Nanjundaswamy S Shashikanth C Anjanamurthy K M Lokanatha Rai |
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| Institution: | Department of Studies in Chemistry , University of Mysore , Manasagangothri, Mysore, 570 006, INDIA |
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| Abstract: | Cyclopropyl ester (8a-f) were synthesized by the cyclopropanation of chalcones (7a-e) in dry benzene using powdered sodium in 80-85% yield. Preparation of tetralone ester (4a-e), an intermediate for the synthesis of podophyllotoxin derivatives by Lewis acid (SnCl4) catalyzed cyclization of (8a-e) is also described here. |
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| Keywords: | Cyclic voltametry McMurry coupling oligothiophenes |
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