Synthesis of 1‐(2,6‐Dimethylphenyl)‐N‐hydroxy‐4,4‐dialkyl‐2,5‐dioxo‐N‐aryl‐3‐pyrrolidine‐carboxamides from Reaction of 2,6‐Dimethylphenyl Isocyanide,Alkylidene Meldrum's Acids,and Arylhydroxylamines |
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| Authors: | Azizollah Habibi Leyla Mousavifar Mohammad R Yazdanbakhsh |
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| Institution: | 1. Faculty of Chemistry , Tarbiat Moallem University , Tehran, Iran;2. Faculty of Chemistry , Tarbiat Moallem University , Tehran, Iran;3. Chemistry Department , Guilan University , Rasht, Guilan, Iran;4. Chemistry Department , Guilan University , Rasht, Guilan, Iran |
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| Abstract: | Alkylidene Meldrum's acids and 2,6‐dimethylphenyl isocyanide react smoothly in the presence of arylhydroxylamines at room temperature to produce 2,5‐dioxo‐pyrrolidines in fairly high yield. |
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| Keywords: | alkylidene Meldrum's acid 2 5‐dioxopyrrolidine heterocyclic synthesis isocyanide three‐component reaction |
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