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A Direct and Efficient Synthetic Method for Nitriles from Ketones |
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| Authors: | Stéphane Kloubert Monique Mathé-Allainmat Jean Andrieux Michel Langlois |
| Affiliation: | CNRS-BIOCIS (UPRES A 8076), Université de Paris-Sud, Faculté de Pharmacie , 5 rue J. B. Clément, 92296, Ch[acaron]tenay-Malabry, France |
| Abstract: | Cyclic cyano derivatives 3 were obtained by the reaction of Me3SiCN / ZnI2 with the cyclic ketones 2 which gave the trimethylsilyloxy nitriles 4. They were directly transformed to cyano derivatives 3 (70–80% yield) by the reductive reagent Me3SiCl-NaI in acetonitrile in the presence of H2O. |
| Keywords: | Stereospecific syntheses trans-2,3-Diaryl-1-aminocyclopropanecarboxylic acid Phenyldiazomethane Oxazolones 1,3-Dipolar cycloaddition |