Asymmetric Induction through Metalation of Chiral Dithioacetals and Oxathioacetals |
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| Authors: | Javid H. Zaidi Naseem Iqbal Gunjial |
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| Affiliation: | 1. Department of Chemistry , Quaid‐i‐Azam University , Islamabad, Pakistan javid_zaidi@yahoo.com;3. Department of Chemistry , Quaid‐i‐Azam University , Islamabad, Pakistan |
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| Abstract: | Abstract The work presented in this article consists of synthesis of chiral dithioacetals and oxathioacetals using pure chiral auxiliaries, such as, (+) camphor, (?) menthol, and L‐cysteine. Metalation of these chiral dithioacetals and oxathioacetals, followed by nucleophilic addition to benzaldehyde and removal of chiral auxiliary, furnished scalemic mandelic acid with various enantiomeric purities. |
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| Keywords: | dithioacetals metalation oxathioacetals |
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