Concise Synthesis of (±)-Clopidogrel via Carboxylation of Benzylamine with CO2 |
| |
Authors: | V Venkataramasubramanian |
| |
Institution: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Pune, Maharashtra, India |
| |
Abstract: | A concise and efficient synthesis of (±)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps. |
| |
Keywords: | Antithrombatic agent clopidogrel CO2 insertion Plavix |
|
|