Condensation of Ortho-phenylenediamines and Phenylhydrazines with Ethyl 4-Chloro-3-oxobutanoate: A Facile Approach for the Synthesis of Substituted 1H-Benzimidazoles,Pyrazolones, and Pyrazoles |
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| Authors: | Cherupally Dayakar Dondra Jyothi Pathi Suman |
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| Affiliation: | Natural Products Chemistry Division, CSIR Indian Institute of Chemical Technology, Hyderabad, India |
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| Abstract: | Substituted 1H-benzimidazoles, pyrazolones, and pyrazoles have been synthesized by the condensation of ortho-phenylenediamines and phenylhydrazines, respectively, with ethyl 4-chloro-3-oxobutanoate in good yields. The present approach is novel, straightforward, and being reported for the first time with ethyl 4-chloro-3-oxobutanoate. |
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| Keywords: | Ethyl 4-chloro-3-oxobutanoate Lewis acids pyrazoles pyrazolones substituted 1H-benzimidazoles |
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