Microwave Irradiation for Accelerating Synthesis of 5,6-Diphenylimidazo[1,2-a]pyrimidines Based on Isoflavones |
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| Authors: | Wen-Yong Han Li Qiu Gang Li |
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| Institution: | Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, and School of Chemistry and Materials Science, Shaanxi Normal University , Xi'an , China |
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| Abstract: | Microwave irradiation was used to accelerate the cyclocondensation of isoflavones with 2-aminoimidazole to synthesize 5,6-diphenylimidazo1,2-a]pyrimidines. A series of 17 new compounds were characterized by Fourier transform infrared, NMR, and elemental analysis. 5-(2-Hydroxyl-4-isopropoxyphenyl)-6-phenylimidazo-1,2-a]pyrimidine was determined by x-ray diffraction. A variety of substrates can participate in the process with good yields and purities, making this methodology suitable for library synthesis in drug discovery.  |
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| Keywords: | Cyclocondensation imidazo[1 2-a]pyrimidine isoflavone microwave irradiation |
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