Synthesis of New Pyrroline Nitroxides with Ethynyl Functional Group |
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Authors: | Györgyi Úr Tamás Kálai Mária Balog Balázs Bognár Gergely Gulyás-Fekete |
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Affiliation: | 1. Institute of Organic and Medicinal Chemistry, University of Pécs, Pécs, Hungary;2. Szentágothai Research Centre, Pécs, Hungary;3. Department of Pharmacognosy, University of Pécs, Pécs, Hungary |
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Abstract: | 3-Substituted and 3,4-disubstituted pyrroline nitroxides containing an ethynyl group or two ethynyl groups were achieved by the reaction of a paramagnetic aldehydes with dimethyl (1-diazo-2-oxopropyl)phosphonate (Bestmann–Ohira reagent). The new compounds containing an ethynyl group were found to be useful building blocks in Sonogashira coupling, cyclization, and cycloaddition reactions producing potentially “azido-specific” cross-linking spin labels, paramagnetic ligands, and polyradical scaffolds. |
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Keywords: | Alkynes cyclization ligand nitroxides Sonogashira coupling |
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