Reaction of Isatoic Anhydride,Amine, and N,N′-Dialkyl Carbodiimides Under Solvent-Free Conditions: New and Efficient Synthesis of 3-Alkyl-2-(alkylamino)quinazolin-4(3H)-ones |
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| Authors: | Mehdi Asadi Mostafa Ebrahimi Mohammad Mahdavi Mina Saeedi Parviz Rashidi Ranjbar Farshad Yazdani |
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| Institution: | 1. School of Chemistry, University College of Science, University of Tehran , Tehran , Iran;2. Chemistry and Chemical Engineering Research Center of Iran , Tehran , Iran;3. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center , Tehran University of Medical Sciences , Tehran , Iran |
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| Abstract: | Heating a mixture of isatoic anhydride, amines, and N,N′-dialkyl carbodiimides under solvent-free conditions provided novel 3-alkyl-2-(alkylamino)quinazolin-4(3H)-one derivatives for the first time. The products were obtained in moderate to good yields without formation of any by-products. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. |
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| Keywords: | 3-Alkyl-2-(alkylamino)quinazolin-4(3H)-ones isatoic anhydride N N′-dialkyl carbodiimides solvent-free |
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