Department of Chemistry , Gauhati University , Guwahati, Assam, India
Abstract:
An efficient method has been developed for the synthesis of epoxide from cinnamic esters without any catalyst. The reaction was performed in CH3CN–water (4:1) using N,N-dibromo-p-toluenesulfonamide (TsNBr2) in alkaline conditions. This procedure can be utilized for stereoselective synthesis of epoxides from cinnamic esters in excellent yield in a shorter reaction time with exclusive formation of the trans-isomer. The method was further extended successfully for styrenes.