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Synthesis of Novel Pyrrolo-[3,2-c]quinolines via Iron-Catalyzed Cross-Coupling Reaction of Grignard Reagents |
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| Authors: | Evelina Colacino Hafid Benakki Farhate Guenoun Jean Martinez |
| Affiliation: | 1. Institute of Biomolecules Max Mousseron, University of Montpellier , Montpellier, France;2. Institute of Biomolecules Max Mousseron, University of Montpellier , Montpellier, France;3. My Isma?l University, Faculty of Sciences , Meknès, Morocco;4. My Isma?l University, Faculty of Sciences , Meknès, Morocco |
| Abstract: | Cross-coupling reaction of alkyl and aryl magnesium halides with 4-chloro-pyrrolo-[3,2-c]quinoline in the presence of a catalytic amount of iron salt is described. The reactions are completed in 30 min, resulting in moderate to excellent yields of 52–94% in a tetrahydrofuran (THF)–N-methylpyrrolidinone (NMP) solvent mixture. |
| Keywords: | Cross-coupling imidoyl chloride iron catalysis nitrogen heterocycles organomagnesium reagents |