Conventional and Microwave-Assisted Facile One-Pot Synthesis of N-Substituted Pyrrole-2,3,4,5-tetracarboxylates Under Neat Conditions |
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| Authors: | H Valizadeh M M Heravi M Amiri |
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| Institution: | 1. Department of Chemistry , Azarbaijan University of Tarbiat Moallem , Tabriz, Iran h-valizadeh@azaruniv.edu;3. Department of Chemistry , Azzahra University , Vanak, Tehran, Iran;4. Department of Chemistry , Azarbaijan University of Tarbiat Moallem , Tabriz, Iran |
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| Abstract: | Highly substituted pyrroles 3a,f were prepared conveniently in a reaction of (dimethyl- and diethyl-)acethylenedicarboxylates 1a–b with N-(methyl- and aryl-) hydroxylamines 2a–d in the presence of NaHCO3 using both conventional heating and microwave irradiation. Excelent yields of the very pure products were isolated under solvent-free conditions both at classical as well as microwave heating. |
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| Keywords: | Dimethylacethylenedicarboxylate methylhydroxylamine neat conditions phenylhydroxylamines pyrrole |
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