Oxidation studies on Andrographolide |
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| Authors: | Mathad Vijayavitthal T Kumar Satish Raj Kanwal |
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| Institution: | Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow-226001, India. kanwalraj12@rediffmail.com |
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| Abstract: | Jones oxidation of Andrographolide (1), gave mixture of three products (3-dehydroandrographolide (5), 3,19-bis dehydroandrographolide (6) and 19-dehydroandrographolide (7). Tritylation of andrographolide at C19-OH resulted to products 8 and diene 9, which can be converted to its acetate 10 and oxidation product 11. |
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