Isolation, structure, and synthesis of dolastatin C, a new depsipeptide from the sea hare Dolabella auricularia |
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| Authors: | Hiroki Sone Takayuki Nemoto Makoto Ojika Kiyoyuki Yamada |
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| Affiliation: | Department of Chemistry, Faculty of Science, Nagoya University, Chikusa, Nagoya 464, Japan |
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| Abstract: | Dolastain C (1), a new depsipeptide exhibiting weak cytotoxicity, has been isolated from the Japanese sea hare Dolabella auricularia. The structure of 1 was elucidated by spectroscopic analysis and chemical degradation. The synthesis of 1 was carried out to confirm the structure unambiguously. |
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