| Trichobitacin-a new ribosome-inactivating protein Ⅰ.The isolation,physicochemical and biological properties of trichobitacin |
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| 作者姓名： | JIN Shan-Wei XIANG Bang-Ping CAO Bai-Xun WANG Yu Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai China |
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| 作者单位： | JIN，Shan-Wei XIANG，Bang-Ping CAO，Bai-Xun WANG，Yu Shanghai Institute of Organic Chemistry，Chinese Academy of Sciences，Shanghai 200032，China |
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| 基金项目： | Project supported by grants from the High Technology Development Program of China,from the Key Project of Chinese Academy 8.5 and from the National Natural Science Foundation of China. |
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| 摘 要： | From the press-residue of the fresh root tuber of Trichosanthes kirilowii Maxim (Cu-curbitaceae),a new ribosome-inactivating protein (RIP),trichobitacin,was isolated.It has the activity of RNA N-glycosidase and can inhibit the growth of human placental trophoblastic cells.Its molecular weight is 27,228 Da (ES-MS) and pI 9.6.It is a single chain basic RIP.Its amino acid composition was determined.It is a new RIP.It consists of 0.7~0.9% galactose and may be a glycoprotein.Its A'-and C-terminal amino acid is Asp and Ala,respectively.Its N-terminal preliminary amino acid sequence has been determined.
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