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Total synthesis of topsentolide B2 |
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| Authors: | Rodney A. Fernandes Pullaiah Kattanguru |
| Affiliation: | Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400 076, Maharashtra, India |
| Abstract: | A stereoselective total synthesis of topsentolide B2, a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield. |
| Keywords: | Topsentolides Stereoselective synthesis Asymmetric dihydroxylation Roush allylation Ring closing metathesis (RCM) |
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