In vivo oral insulin delivery via covalent organic frameworks |
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| Authors: | Farah Benyettou,Nawel Kaddour,Thirumurugan Prakasam,Gobinda Das,Sudhir Kumar Sharma,Sneha Ann Thomas,Fadia Bekhti-Sari,Jamie Whelan,Mohammed A. Alkhalifah,Mostafa Khair,Hassan Traboulsi,Renu Pasricha,Ramesh Jagannathan,Nassima Mokhtari-Soulimane,Felipe Gá ndara,Ali Trabolsi |
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| Affiliation: | New York University Abu Dhabi, P.O. Box 129188, Abu Dhabi United Arab Emirates.; Laboratory of Physiology Physiopathology and Biochemistry of Nutrition, Department of Biology, University of Tlemcen, Algeria ; Department of Chemistry, College of Science, King Faisal University, P.O. Box 400, Al-Ahsa, 31982 Saudi Arabia ; School of Chemistry, University of Bristol, Cantocks Close, Bristol BS8 1TS UK ; Materials Science Institute of Madrid – CSIC, Spain |
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| Abstract: | With diabetes being the 7th leading cause of death worldwide, overcoming issues limiting the oral administration of insulin is of global significance. The development of imine-linked-covalent organic framework (nCOF) nanoparticles for oral insulin delivery to overcome these delivery barriers is herein reported. A gastro-resistant nCOF was prepared from layered nanosheets with insulin loaded between the nanosheet layers. The insulin-loaded nCOF exhibited insulin protection in digestive fluids in vitro as well as glucose-responsive release, and this hyperglycemia-induced release was confirmed in vivo in diabetic rats without noticeable toxic effects. This is strong evidence that nCOF-based oral insulin delivery systems could replace traditional subcutaneous injections easing insulin therapy.We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin. |
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