Synthesis of novel gem-difluorinatedcyclopropane hybrids: Applications for DNA cleavage agents switched by photo irradiation |
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| Institution: | 1. Department of Materials Science, Faculty of Engineering, Tottori University, Tottori 680–8552, Japan;2. Institute of Chemical Research, Kyoto University, Uji 611–0011, Japan;3. Department of Biosciences and Biotechnology, Faculty of Engineering, Okayama University, Okayama 700–8530, Japan;1. Department of Analytical Chemistry, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain;2. Biomolecular Analysis, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands;3. AIMMS Division of BioAnalytical Chemistry, VU University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands;1. Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA 30329, United States;2. Center for Translational Social Neuroscience, Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Atlanta, GA 30322, United States;1. Faculty of Pharmacy, Chiba Institute of Science, 15-8 Shiomi-cho, Choshi, Chiba 288-0025, Japan;2. Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;1. KU Leuven – University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, B-3000 Leuven, Belgium;2. Stanford University, Departments of Chemistry and Chemical and Systems Biology, CA 94305, USA |
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| Abstract: | A strong DNA cleavage property switched by photo irradiation was found for 9-anthracenecarboxylic acid substituted gem-difluorocyclopropane derivatives; in particular, a clear contrast in the activity was observed between the enantiomers of (S,S)- and (R,R)-3-aminomethyl-2,2-difluorocyclopropylmethyl 9-anthracenecarboxylate. |
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