Lipophilicity determination of some new crown ethers by reversed-phase thin-layer chromatography |
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| Authors: | T Cserháti M Szögyi L Györfi |
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| Institution: | (1) Plant Protection Institute of the Hungarian Academy of Sciences, 15 Herman Otto Street, H-1022 Budapest, Hungary;(2) Institute for Biophysics, Semmelweis Medical University, 9 Puskin Street, H-1088 Budapest, Hungary;(3) Plant Protection and Agrochemistry Centre, Agriculture and Food Ministery, 141 Budaörsi Street, H-1502 Budapest, Hungary |
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| Abstract: | Summary The lipophilicity of 28 modified crown ether derivatives was determined by reversed-phase thin-layer chromatography (RPTLC) using various organic phases and supports. The lipophilicity values determined in different RPTLC systems showed good correlations, however the quality of the organic phase (methanol, acetone, acetonitrile) and the support characteristics influenced to a small extent the determination. |
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| Keywords: | Reversed-phase TLC Crown ether derivatives Quantitative-Structure-Activity Relationship Lipophilicity |
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