Monitoring performance of nucleic acid-based diagnostic measurement system users by EQA |
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| Authors: | H J Staines L Garcia-Fernandez R Pogothata P S Wallace W G MacKay A M Van Loon |
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| Institution: | (1) Sigma Statistical Services Ltd, Balmullo, KY16 0BJ, St., St. Andrews, Scotland, UK;(2) University of Abertay Dundee, Kydd Building, 40 Bell Street, Dundee, DD1 1HG, Scotland, UK;(3) Quality Control for Molecular Diagnostics, Block 4.1, Kelvin Campus, West of Scotland Science Park, Glasgow, G20 0SP, Scotland, UK |
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| Abstract: | External quality assurance (EQA) programmes allow a laboratory to monitor independently its performance and provide feedback
to identify and investigate potential areas of concern. However, both the definition of appropriate ‘performance indicators’
and their statistical analysis vary across EQA providers. Typically, performance scores have an unknown statistical distribution
and hence arbitrary thresholds are used to measure performance. In this paper, we introduce a scoring system based on well-known
statistical principles. The system is simple, flexible and easy to interpret. It can be used to measure performance for single
samples or across a panel so providing useful and meaningful information to participants in EQA programmes. The score is illustrated
using the 2005 QCMD Hepatitis B Virus Proficiency programme. |
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| Keywords: | Quality assessment Scoring system Nucleic acid-based diagnostics Proficiency test data Statistical methods Bayesian model |
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