An efficient synthesis of the natural tetrahydrofuran pachastrissamine starting from D-ribo-phytosphingosine |
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| Authors: | van den Berg Richard J B H N Boltje Thomas J Verhagen Carlo P Litjens Remy E J N van der Marel Gijsbert A Overkleeft Herman S |
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| Institution: | Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA Leiden, The Netherlands. |
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| Abstract: | reaction: see text] The natural product pachastrissamine, an anhydrophytosphingosine derivative isolated from various sponges and endowed with cytotoxic activity against several human carcinoma cell lines, was synthesized in three steps and with 72% overall yield from d-ribo-phytosphingosine. |
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