Biochemical characterization of the maltokinase from <Emphasis Type="Italic">Mycobacterium bovis</Emphasis> BCG |
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| Authors: | Vítor Mendes Ana Maranha Pedro Lamosa Milton S da Costa Nuno Empadinhas |
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| Institution: | 1.Center for Neuroscience and Cell Biology,University of Coimbra,Coimbra,Portugal;2.Instituto de Tecnologia Química e Biológica,Universidade Nova de Lisboa,Oeiras,Portugal;3.Centro de Ressonancia Magnética António Xavier, Instituto de Tecnologia Química e Biológica,Universidade Nova de Lisboa,Oeiras,Portugal;4.Department of Life Sciences,University of Coimbra,Coimbra,Portugal |
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| Abstract: | Background Maltose-1-phosphate was detected in Mycobacterium bovis BCG extracts in the 1960's but a maltose-1-phosphate synthetase (maltokinase, Mak) was only much later purified from Actinoplanes missouriensis, allowing the identification of the mak gene. Recently, this metabolite was proposed to be the intermediate in a pathway linking trehalose with the synthesis of
glycogen in M. smegmatis. Although the M. tuberculosis H37Rv mak gene (Rv0127) was considered essential for growth, no mycobacterial Mak has, to date, been characterized. |
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