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Synthesis of tetrazolodiazepines by a five-centered four-component azide Ugi reaction. Scope and limitations |
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| Authors: | R S Borisov A I Polyakov L A Medvedeva N I Guranova L G Voskressensky |
| Institution: | 1214. A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, 29 Leninsky prosp., 119991, Moscow, Russian Federation 2214. N. N. Blokhin Russian Cancer Scientific Center, Russian Academy of Medical Sciences, 24 Kashirskoe shosse, 115478, Moscow, Russian Federation 3214. Peoples’ Frendship University of Russia, 6 ul. Miklukho-Maklaya, 117198, Moscow, Russian Federation |
| Abstract: | Tetrazolo1,5-a]1,4]benzodiazepines were obtained by an efficient azide five-centered four-component Ugi reaction, which used ketones, sodium azide, ammonium chloride, and the corresponding isonitrile. Scope and limitations of this multi-component reaction were considered. |
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