Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey |
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| Authors: | Hong Liu ShuFang Zheng Véronique Bellemare Georges Pelletier Fernand Labrie Van Luu-The |
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| Institution: | (1) Oncology and Molecular Endocrinology Laboratory, Laval University Hospital Research Center (CRCHUL) and Laval University, Quebec, GlV 4G2, Canada |
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| Abstract: | Background We have recently discovered that human type 12 17β-HSD (h17β-HSD12), a homolog of type 3 17β-HSD, is a new estrogen-specific
17β-hydroxysteroid dehydrogenase involved in the production of estradiol (E2). To further characterize this estradiol-producing
enzyme, we have isolated the corresponding cDNA in the cynomolgus monkey (Macaca fascicularis), characterized its enzymatic activities and performed cellular localization using in situ hybridization. |
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