Mitochondrial respiratory chain is involved in insulin-stimulated hydrogen peroxide production and plays an integral role in insulin receptor autophosphorylation in neurons |
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Authors: | Tatiana P Storozhevykh Yana E Senilova Nadezhda A Persiyantseva Vsevolod G Pinelis Igor A Pomytkin |
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Affiliation: | (1) Scientific Centre for Children's Health, RAMS, Lomonosovsky prospect 2/62, 119991 Moscow, Russia;(2) Biosignal Ltd., M.Gruzinskaya 29-153, 123557 Moscow, Russia |
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Abstract: | Background Accumulated evidence suggests that hydrogen peroxide (H2O2) generated in cells during insulin stimulation plays an integral role in insulin receptor signal transduction. The role of insulin-induced H2O2 in neuronal insulin receptor activation and the origin of insulin-induced H2O2 in neurons remain unclear. The aim of the present study is to test the following hypotheses (1) whether insulin-induced H2O2 is required for insulin receptor autophosphorylation in neurons, and (2) whether mitochondrial respiratory chain is involved in insulin-stimulated H2O2 production, thus playing an integral role in insulin receptor autophosphorylation in neurons. |
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