Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme |
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| Authors: | He Yan-Hong Hu Wen Guan Zhi |
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| Institution: | School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China. |
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| Abstract: | The direct three-component aza-Diels-Alder reaction of aromatic aldehyde, aromatic amine, and 2-cyclohexen-1-one was catalyzed by hen egg white lysozyme for the first time. Under the optimized conditions investigated in this paper, the enzyme-catalyzed aza-Diels-Alder reaction gave yields up to 98% and stereoselectivity of endo/exo ratios up to 90:10. |
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