| 不对称加氢催化剂[Ru(BINAP)(OAc)2]的合成及其固载化研究 |
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| 引用本文： | 徐开俊,王珺,王礼琛,王宫华,丁维平.不对称加氢催化剂[Ru(BINAP)(OAc)2]的合成及其固载化研究[J].化学通报,2006,69(11):841-844. |
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| 作者姓名： | 徐开俊 王珺 王礼琛 王宫华 丁维平 |
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| 作者单位： | 中国药科大学 南京210009(徐开俊，王珺，王礼琛)，南京大学化学化工学院 南京210093(王宫华，丁维平) |
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| 摘 要： | 对文献报道的实验反应条件进行优化改进后,合成了不对称加氢催化剂Ru((S)-BINAP)(OAc)2]和Ru((R)-BINAP)(OAc)2]。将合成的催化剂应用于惕各酸的不对称催化氢化,(S)-2-甲基丁酸得率为88%,立体选择性可达85%e.e.。为了提高催化剂的利用率,将催化剂Ru(BINAP)(OAc)2]负载在新型介孔分子筛SBA-15上,用于惕各酸的不对称催化氢化,循环应用3次后,(S)-2-甲基丁酸得率仍可达到59%,立体选择性达57%e.e.。
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| 关 键 词： | [Ru(BINAP)(OAc)2] 不对称催化氢化 负载SBA-15 |
| 收稿时间： | 2005-12-07 |
| 修稿时间： | 2005-12-072006-07-31 |
The Synthesis of Asymmetric Hydrogenation Catalyst [ Ru(BINAP)( Oac)2 ] and its Solid-supported Studies |
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| Xu Kaijun,Wang Jun,Wang Lichen,Wang Gonghua,Ding Weiping.The Synthesis of Asymmetric Hydrogenation Catalyst [ Ru(BINAP)( Oac)2 ] and its Solid-supported Studies[J].Chemistry,2006,69(11):841-844. |
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| Authors: | Xu Kaijun Wang Jun Wang Lichen Wang Gonghua Ding Weiping |
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| Institution: | China Phannaceutical University, Nanjing 210009 ; College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 2100093 |
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| Abstract: | The two asymmetric hydrogenation catalysts, Ru((S)_BINAP)(OAc)_2] and Ru((R)_BINAP)(OAc)_2], have been synthesized under the optimal experimental conditions. The asymmetric reduction of tiglic acid is efficiently achieved with 88% yield and 85%e.e.(enantiomeric excess) by using the synthesized catalyst. The study on the activity of catalyst Ru(BINAP)(OAc)_2] supported on the mesoporous molecular sieve SBA_15 showed that a relatively high yield (59%) and steroselectivity(57% e.e.) were maintained after recycled for three times. |
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| Keywords: | [Ru(BINAP)(OAc)_2] Asymmetric catalytic hydrogenation Support SBA_15 |
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