| 度洛西汀酰基衍生物的合成 |
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| 引用本文： | 章文军,苑志忠,张静.度洛西汀酰基衍生物的合成[J].合成化学,2012,20(1):123-124,127. |
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| 作者姓名： | 章文军 苑志忠 张静 |
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| 作者单位： | 河北工业大学化工学院,天津,300130 |
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| 摘 要： | 抗抑郁药度洛西汀与取代酰氯反应合成了四个新的度洛西汀酰基衍生物——N-取代酰基-N-甲基-3-(1-萘氧基)-3-(2-噻吩基)丙胺,其结构经1H NMR,IR和MS表征。
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| 关 键 词： | 度洛西汀 抗抑郁药 取代酰氯 合成 |
Synthesis of Duloxetine Derivatives with Acyl |
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| ZHANG Wen-jun
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YUAN Zhi-zhong
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ZHANG Jing.Synthesis of Duloxetine Derivatives with Acyl[J].Chinese Journal of Synthetic Chemistry,2012,20(1):123-124,127. |
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| Authors: | ZHANG Wen-jun YUAN Zhi-zhong ZHANG Jing |
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| Institution: | (School of Chemical Engineering and Technology,Hebei University of Technology,Tianjin 300130,China) |
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| Abstract: | Four novel duloxetine derivatives with acyl,N-(substituted acyl)-N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamines,were synthesized by the reaction of duloxetine with substituted acyl chlorides.The structures were characterized by 1H NMR,IR and MS. |
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| Keywords: | duloxetine antidepressant acyl chloride synthesis |
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