| 柳氮磺胺吡啶的合成工艺改进 |
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| 引用本文： | 金灿,林晓清,苏为科.柳氮磺胺吡啶的合成工艺改进[J].合成化学,2012,20(4):524-526. |
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| 作者姓名： | 金灿 林晓清 苏为科 |
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| 作者单位： | 浙江工业大学药学院制药工程教育部重点实验室,浙江杭州,310014 |
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| 基金项目： | 浙江省自然科学基金资助项目 |
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| 摘 要： | 以磺胺吡啶和NaNO2为原料,在管式反应器中经重氮化反应合成磺胺吡啶重氮盐(2);2再与水杨酸偶合制备了柳氮磺胺吡啶,总收率87%,其结构经1H NMR,13C NMR和MS确证。
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| 关 键 词： | 柳氮磺胺吡啶 重氮化反应 偶合反应 管式反应器 合成 工艺改进 |
Process Improvement on the Synthesis of Sulfasalazine |
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| JIN Can
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LIN Xiao-qing
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SU Wei-ke.Process Improvement on the Synthesis of Sulfasalazine[J].Chinese Journal of Synthetic Chemistry,2012,20(4):524-526. |
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| Authors: | JIN Can LIN Xiao-qing SU Wei-ke |
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| Institution: | (Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | Sulfasalazine was synthesized in total yield of 87% by diazotization of sulfapyridine with NaNO2 in tubular reactor and then coupling with salicylic acid.The structure was confirmed by 1H NMR,13C NMR and MS. |
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| Keywords: | Sulfasalazine diazo reaction coupling reaction tubular reactor synthesis process improvement |
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