| BTC/DMF辅助的1-取代苯基-3,4-二取代吡唑类衍生物的合成 |
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| 引用本文： | 陈志卫,刘峰帆,苏为科.BTC/DMF辅助的1-取代苯基-3,4-二取代吡唑类衍生物的合成[J].合成化学,2012,20(1):69-72. |
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| 作者姓名： | 陈志卫 刘峰帆 苏为科 |
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| 作者单位： | 浙江工业大学药学院制药工程教育部重点实验室,浙江杭州,310014 |
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| 摘 要： | 室温条件下,以各种取代苯肼和环状酮为起始原料,经脱水成腙和Vilsmeier试剂(BTC/DMF)环合两步反应合成了1-取代苯基-3,4---取代吡唑类衍生物(4a～4i),其结构经1H NMR,13C NMR,IR和MS表征,其中4b,4c,4e,4f和4h为新化合物.
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| 关 键 词： | 1-取代苯基-3 4-二取代吡唑 Vilsmeier试剂 BTC 合成 |
Synthesis of 1-( Substituted phenyl) -3,4-disubstituted-pyrazole Derivatives by BTC/DMF Assistant |
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| CHEN Zhi-wei
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LIU Feng-fan
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SU Wei-ke.Synthesis of 1-( Substituted phenyl) -3,4-disubstituted-pyrazole Derivatives by BTC/DMF Assistant[J].Chinese Journal of Synthetic Chemistry,2012,20(1):69-72. |
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| Authors: | CHEN Zhi-wei LIU Feng-fan SU Wei-ke |
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| Institution: | (Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | 1-Phenyl-3,4-disubstituted-pyrazole derivatives(4a~4i) were synthesized from various substituted phenylhydrazine reacted with cyclic ketone,followed by cyclizations with Vilsmeier reagent generated in situ from bis(trichloromethyl)carbonate(BTC) and DMF at room temperature.The structures were confirmed by 1H NMR,13C NMR,IR and MS.4b,4c,4e,4f and 4h were new compounds. |
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| Keywords: | 1-phenyl-3 4-disubstituted-pyrazole Vilsmeier reagent BTC synthesis |
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