| 合成萘普西诺的工艺改进 |
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| 引用本文： | 江传亮,陈国华,潘瑜群,李素义. 合成萘普西诺的工艺改进[J]. 合成化学, 2012, 20(1): 128-129 |
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| 作者姓名： | 江传亮 陈国华 潘瑜群 李素义 |
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| 作者单位： | 中国药科大学药物化学系,江苏南京,210009 |
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| 摘 要： | 以(S)-萘普生为原料,经酯化、硝酸酯化反应合成了萘普西诺,总收率39.9%,纯度99.1%,其结构经1H NMR,IR和MS确证。
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| 关 键 词： | 萘普西诺 (S)-萘普生 药物合成 工艺改进 |
Process Improvement on the Synthesis of Naproxcinod |
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| JIANG Chuan-liang , CHEN Guo-hua , PAN Yu-qun , LI Su-yi. Process Improvement on the Synthesis of Naproxcinod[J]. Chinese Journal of Synthetic Chemistry, 2012, 20(1): 128-129 |
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| Authors: | JIANG Chuan-liang CHEN Guo-hua PAN Yu-qun LI Su-yi |
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| Affiliation: | (Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China) |
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| Abstract: | Naproxcinod was synthesized from(S)-naproxen by esterification,then nitration in overall yield of 39.9% with purity 99.1%.The structure was confirmed by 1H NMR,IR and MS. |
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| Keywords: | naproxcinod (S)-naproxen drug synthesis process improvement |
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