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Efficient total synthesis of (+)-negamycin, a potential chemotherapeutic agent for genetic diseases |
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| Authors: | Hayashi Yoshio Regnier Thomas Nishiguchi Shigenobu Sydnes Magne O Hashimoto Daisuke Hasegawa Junya Katoh Takahiro Kajimoto Tetsuya Shiozuka Masataka Matsuda Ryoichi Node Manabu Kiso Yoshiaki |
| Institution: | Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8412, Japan. yhayashi@ps.toyaku.ac.jp |
| Abstract: | Herein, we describe an efficient strategy for the total synthesis of (+)-negamycin using commercially available achiral N-Boc-2-aminoacetaldehyde as starting material with 42% overall yield for a limited number of steps. |
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