A novel synthesis of highly substituted imidazo[1,5-a]pyrazine derivatives by 3-CR/2-CR sequence |
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| Authors: | Ahmad Shaabani Ali Maleki Hamid Mofakham |
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| Institution: | (1) Department of Chemistry, Shahid Beheshti University, P. O. Box 19396-4716, Tehran, Iran |
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| Abstract: | By combining a three-component reaction of 2, 3-diaminomaleonitrile, ketones and isocyanides with a subsequent reaction of
1,6-dihydropyrazine-2,3-dicarbonitrile derivatives obtained from isocyanide-based three-component reaction with various alkyl
and aryl isocyanates or isothiocyanates can be assembled a new class of highly substituted imidazo1,5-a]pyrazine derivatives. |
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| Keywords: | Imidazo[1 5-a]pyrazine Isocyanide Isocyanate 2 3-Diaminomaleonitrile Multicomponent reaction |
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