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Macrocyclisation of 2-(5-(2-hydroxyethyl)furan-2-yl)acetic acid model compounds of nonactic acid |
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| Authors: | Carine Eng Jean-Mary Simone Akane Hartenbach François Loiseau Reinhard Neier |
| Institution: | (1) Department of Chemistry, University of Neuchatel, Avenue Bellevaux 51, 2007 Neuchatel, Switzerland |
| Abstract: | Abstract The macrocyclisation of hydroxyethylfuranyl acetic acid and of dehydrogenated model compounds of nonactic acid was investigated
to develop a facile synthesis of nonactin analogues. By applying the Yamagushi macrocyclisation to our ω-hydroxyacids, we were able to isolate a mixture of di-, tri-, tetra- and pentameric macrocycles.
Graphical abstract
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| Keywords: | Heterocycles Macrocycles Natural product analogues Nonactin Protecting groups |
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