Product design based on discrete particle modeling of a fluidized bed granulator |
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Institution: | 1. Dipartimento di Ingegneria dell''Impresa, Università degli Studi di Roma Tor Vergata, Via del Politecnico 1, 00133 Rome, Italy;2. Dipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università degli Studi di Roma, Via Eudossiana 18, 00184 Rome, Italy;3. Dipartimento di Ingegneria Informatica Automatica e Gestionale Antonio Ruberti, Sapienza Università degli Studi di Roma, Via Ariosto 25, 00185 Rome, Italy;1. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland;2. Control Engineering Laboratory, Department of Process and Environmental Engineering, University of Oulu, P.O. Box 4300 FI-90014, Finland;3. VTT Optical Instruments, VTT Technical Research Centre of Finland, P.O. Box 1199, FI-70211 Kuopio, Finland |
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Abstract: | Fluidized bed agglomeration is a process commonly used to construct powdered food or pharmaceutical products to improve their instant properties. This works analyzes the influence of a wide range of operating parameters (i.e., fluidization air flow rate, temperature, and liquid injection rate) on growth rate, process stability, and product particle structure. Different granulator configurations (i.e., top spray, Wurster coater, spouted bed) are compared using identical process parameters. The impacts of both process variables and granulator geometry on the fluidization regime, the particle and collision dynamics, and the resulting product structure and corresponding properties are studied in detailed simulations using a discrete particle model (DPM) and lab-scale agglomeration experiments with amorphous dextrose syrup (DE21). The combination of numerical and experimental results allows to correlate the kinetics of micro-scale particle interactions and the final product properties (i.e., agglomerate structure and strength). In conclusion, detailed DPM simulations are proven as a valuable tool for knowledge-based product design. |
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Keywords: | Fluidization Agglomeration Discrete element method Food powder Collision dynamics |
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