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Preparation and characterization of graphene nanosheets dispersed pyrrole-chorobenzaldehyde-heptaldehyde conjugated terpolymer nanocomposites for DNA detection |
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| Authors: | Pangajam Annamalai Chandramohan Ayyavu Dinakaran Kannaiyan Harichandran Gurusamy Sureshkumar R |
| Institution: | 1.Department of Chemistry, Thiruvalluvar University, Vellore, 632 115, India ;2.Department of Chemical Engineering, Sri SivasubramaniyaNadar College of Engineering, Old Mahabalipuram Rd, OMR, Kalavakkam, 603110, Tamil Nadu, Chennai, India ;3.Department of Polymer Science, University of Madras, Guindy Campus, Chennai, 600 025, India ;4.Department of Chemistry, R.V.Govt Arts College, Changalpattu, 632101, India ; |
| Abstract: | A new conductive terpolymer/graphene nanosheet hybrid composite has been synthesized by polymerizing pyrrole, chlorobenzaldehyde, and heptaldehyde (PPyCB&;H), in the presence of graphene nanosheets (GNS), using p-toluene sulfonic acid as a catalyst. Fourier transform infrared spectra, proton nuclear magnetic resonance, transmission electron microscopy, and X-ray diffraction patterns confirm the formation of PPyCB&;H/GNS hybrid nanocomposites. Further, the resultant nanocomposite material is coated on ITO to construct an electrochemical sensor for the reliable detection of single-strand DNA (tDNA) which is cleaved from the genomic DNA of Escherichia coli. Under optimized conditions, linear detection of genomic DNA (tDNA) with concentration ranging from 1.3?×?10?12 to 1.3?×?10?23 M is observed and it is repeatable with a 1.3?×?10?23 M lowest level detection limit. The present modified electrode of PPyCB&;H/GNS may show utility for constructing highly sensitive electrochemical sensors for the detection of E. coli. Graphical abstract |
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