Structural features of hydroxyapatite and carbonated apatite formed under the influence of ultrasound and microwave radiation and their effect on the bioactivity of the nanomaterials |
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Institution: | 1. Sumy State University, Ministry of Education and Science of Ukraine, Sumy 40007, Ukraine;2. Institute of Applied Physics, National Academy of Sciences of Ukraine, Sumy 40000, Ukraine;3. Kyiv National Taras Shevchenko University, Ministry of Education and Science of Ukraine, Kyiv 01601, Ukraine;4. Sumy National Agrarian University, Sumy 40000, Ukraine |
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Abstract: | The samples of hydroxyapatite and carbonate substituted hydroxyapatite (CHA) were obtained under the influence of physical factors, namely ultrasound (US) and microwave (MW) radiations. The results of Fourier transform infrared spectroscopy and X-ray diffraction analysis have proved the formation of the calcium deficient hydroxyapatite and B-type CHA with the Ca/P ratio in the ranges 1.62–1.87. In vitro studies have showed the increased bioactivity of the samples, synthesized under the influence of physical factors as compared to the standard ones. The samples of both groups, synthesized under the influence of 600 W MW, have shown the greatest stability in biological environment. In vivo tests confirm that obtained under US and MW radiations hydroxyapatite-based biomaterials are biocompatible, non-toxic and exhibit osteoconductive properties. The usage of US and MW radiations can significantly shorten the time (up to 5–20 min) of obtaining of calcium deficient hydroxyapatite and B-type CHA in nanopowder form, close in structure and composition to the biological hydroxyapatite. |
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Keywords: | Ultrasound Microwave Carbonate hydroxyapatite Crystal lattice Nanopowder Bioactivity |
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