Synthesis of sterically congested 1,3,4-oxadiazole derivatives from aromatic carboxylic acids, N,N-dicyclohexylcarbodiimide and (N-isocyanimino)triphenylphosphorane
(1) Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran;(2) Young Researchers Club, Islamic Azad University, Zanjan Branch, Zanjan, Iran;
Abstract:
Reactions of (N-isocyanimino)triphenylphosphorane with N,N-dicyclohexylcarbodiimide in the presence of aromatic (or heteroaromatic) carboxylic acids proceed smoothly at room temperature and in neutral conditions to afford sterically congested 1,3,4-oxadiazole derivatives in high yields. The reaction proceeds smoothly and cleanly under mild conditions, and no side reactions were observed.
