Separation of cinchona alkaloids, opium alkaloids, heroin, and related narcotics by dynamic-coating high-speed liquid chromaotgraphy |
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| Authors: | C Y Wu S Siggia T Robinson R D Waskiewicz |
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| Institution: | Department of Chemistry, Amherst, Mass. 01002 U.S.A.;Department of Biochemistry,Amherst, Mass. 01002 U.S.A.;State Department of Public Health, Division of Food and Drugs, Western Massachusetts Public Health Center, University of Massachusetts, Amherst, Mass. 01002 U.S.A. |
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| Abstract: | High-speed liquid chromatography can provide successful separations of two cinchona alkaloids, four opium alkaloids, or heroin-related narcotics. Poly G-300 is used as the liquid stationary phase. Both mechanical-coating and dynamic-coating techniques are employed; dynamic-coating techniques appear to be advantageous for some cases. With the latter technique the degree of partition and adsorption separation mechanisms can be controlled to facilitate separations which might be difficult otherwise. Quantitative analysis of three rapidly eluting opium alkaloids, at nanogram to microgram levels, is described; reasonable accuracy (± 10% or better) was obtained. |
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